Beilstein J. Org. Chem.2021,17, 2462–2476, doi:10.3762/bjoc.17.163
, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, 92 Aiguo Road, Nanchang, Jiangxi, 330006, China 10.3762/bjoc.17.163 Abstract Great progress has been made in the tandemannulation of enynes in the past few years. This review only presents the corresponding reactions of 1,3-enyne
introduce the applications of the products and the reaction mechanisms for the synthesis of corresponding N-heterocycles.
Keywords: 1,3-enyne; functionalization; pyridine; pyrrole; tandemannulation; Introduction
The pyridine moiety is an important class of six-membered N-heterocycles that is widely found
synthesis [47]. Further, the Liu group reviewed the synthesis of allenes via transition metal-catalyzed 1,4-functionalizations of unactivated 1,3-enynes [48]. In this review, we will highlight the recent advances in the tandemannulation reactions of 1,3-enyne structural motifs for the construction of
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Graphical Abstract
Scheme 1:
Ag/I2-mediated electrophilic annulation of 2-en-4-ynyl azides 1.